In the interview, James discusses his I Promise School, a public elementary school which he opened in his hometown of Akron, Ohio.
James also talked about social issues and Trump's comments about sports in the past.
In response, Trump tweeted "Lebron James was just interviewed by the dumbest man on television, Don Lemon. He made Lebron look smart, which isn't easy to do. I like Mike!"
Lemon responded Saturday morning by calling out the president's controversial immigration policies.
The tweet did not go over well in the sport world or beyond with many reacting on social media.
Here are some of the reactions from NBA athletes:
Others, including Ohio governor John Kasich have responded.
James tweeted about the I Promise school, saying "Love you guys."
He didn't say anything specific about Trump's tweet.