PHILADELPHIA (3-0) at SAN FRANCISCO (1-2)
Sunday, 4:25 p.m. ET, Fox
OPENING LINE - 49ers by 3 1/2
RECORD VS. SPREAD - Philadelphia 2-1, San Francisco 1-2
SERIES RECORD - 49ers lead 18-12-1
LAST MEETING - 49ers beat Eagles 24-23, Oct. 2, 2011
AP PRO32 RANKING - Eagles No. 4, 49ers No. 15
EAGLES OFFENSE - OVERALL (6), RUSH (19), PASS (2).
EAGLES DEFENSE - OVERALL (26), RUSH (13), PASS (30).
49ERS OFFENSE - OVERALL (20T), RUSH (17), PASS (17).
49ERS DEFENSE - OVERALL (6), RUSH (7), PASS (14T).
STREAKS, STATS AND NOTES - Eagles won five of past six meetings. Loss came in 2011 in coach Jim Harbaugh's first season in San Francisco. ... Harbaugh split two meetings in college at Stanford vs. Eagles coach Chip Kelly, who was at Oregon. ... Eagles first team in NFL history to start 3-0 after trailing by at least 10 points in every game. ... Philadelphia leads NFL with 116 plays of at least 20 yards since Kelly became coach last season. ... Nick Foles looks to become first Eagles QB with four straight 300-yard passing games. ... Philadelphia has takeaway in 16 straight games, including playoffs. ... Eagles rookie WR Jordan Matthews is cousin of Niners Hall of Famer Jerry Rice. ... 49ers look to avoid first three-game losing streak in four seasons with Harbaugh. ... San Francisco S Antoine Bethea is set to start 100th consecutive game, longest active streak by any DB. ... WRs Michael Crabtree (10 catches vs. Arizona) and Stevie Johnson (nine catches) gave Niners first pair of receivers with at least nine catches in game since Rice and Terrell Owens did it vs. Cincinnati in 1999. ... San Francisco RB Frank Gore is only player with three 100-yard rushing games vs. Eagles since 2008.
AP NFL website: www.pro32.ap.org and http://twitter.com/AP-NFL