Week 3 NFL Score Predictions

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Every week, I'll release a prediction for every game in the NFL. Here's how I see things going down in Week 3.
WEEK 1 PICKS: 8-7.
SEASON PICKS: 15-16.
Giants at 49ers
This kind of feels like a bit of a flat spot for the Niners, so I wouldn't be all that surprised to see them sputter out of the gates. The deeper we get into the game, the more San Fran will get back to themselves and run right through New York.
Prediction: 49ers 27, Giants 10.
Colts at Ravens
Indy was competitive in Week 1 with the Jags and took care of business last week against the Texans. They put up a good fight again this week but fall a little short.
Prediction: Ravens 20, Colts 17
Titans at Browns
Cleveland bounces back after losing a tough one on the road in Pittsburgh Monday night.
Prediction: Browns 23, Titans 21.
Broncos at Dolphins
Not even Sean Payton can fix this team. The Broncos get crushed and fall to 0-3 on the season.
Prediction: Dolphins 38, Broncos 17.
Patriots at Jets
Both of these teams desperately need a win, the Pats probably more so than the Jets. New York's defense is too talented and absolutely stifles Mac Jones and company.
Prediction: Jets 19, Patriots 9.
Bills at Commanders
The Commanders are a sneaky 2-0 and may not have the full attention of the visiting Bills. Buffalo wins, but it's not pretty.
Prediction: Bills 26, Commanders 22.
Falcons at Lions
Detroit could very easily be 2-0 riding into this matchup and there's no shame in losing to Seattle. This is going to be a tough, physical football game that will be won and lost in the trenches. Give me the Lions.
Prediction: Lions 28, Falcons 24.
Saints at Packers
For the first time in ten games, the Saints will give up more than 20 points. New Orleans' offense has not looked sharp and I see that side of the ball continuing to struggle in Week 3.
Prediction: Packers 21, Saints 13.
Texans at Jaguars
C.J. Stroud has looked the best of the rookie QBs so far this season, but this is a tough challenge for him against a stingy Jags' D.
Prediction: Jaguars 30, Texans 14.
Chargers at Vikings
Two playoff contenders clash in Minnesota and one of them will leave with a sour taste in their mouth with an 0-3 start to the season. I'm not big on Brandon Staley, so give me the Vikings.
Prediction: Vikings 31, Chargers 23.
Panthers at Seahawks
Andy Dalton appears to be in at quarterback this week for the Panthers with Bryce Young missing the first two practices of the week. His experience will help the offense deal with the tough environment but I'm not sure it makes a difference in the outcome of the game.
Prediction: Score prediction will be posted tomorrow.
Cowboys at Cardinals
The Cowboys have outscored their opponents 70-10 through two weeks of football. That point differential will increase significantly again this Sunday.
Prediction: Cowboys 38, Cardinals 7.
Bears at Chiefs
It's been quite the week in Chicago. A lot of distractions for a team that already has a hard time being competitive. Chiefs coast.
Prediction: Chiefs 34, Bears 13.
Steelers at Raiders
This is a coin flip if you ask me. I'm a little concerned with the Steelers offense, so I'll give the slight edge to Vegas.
Prediction: Raiders 17, Steelers 16.
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Schuyler Callihan is the publisher of West Virginia On SI and has been a trusted source covering the Mountaineers since 2016. He is the host of Between The Eers, The Walk Thru Game Day Show, and In the Gun Podcast. The Wheeling, WV native moved to Charlotte, North Carolina in 2020 to cover the Charlotte Hornets and Carolina Panthers.