Samuel went down with 5:10 to play in the second quarter after a three-yard carry on second-and-9 from the Tampa Bay 43-yard line. He appeared to suffer the injury after his left leg rolled up underneath him and bent awkwardly as he was getting tackled on the play. After the hit, he was seen on the ground in noticeable pain while holding his left knee.

The Niners’ medical staff rushed onto the field to evaluate the fourth-year wideout, who initially attempted to walk off the field under his own power. However, the team ended up calling for a cart to take a visibly emotional Samuel to the locker room after he gingerly attempted to make his way to the sidelines.