Charles sustained a high ankle sprain against the Broncos in Week 2. He practiced before Kansas City's Week 3 game against the Dolphins but did not play.
Last week, Chiefs coach Andy Reid said he was optimistic about Charles' chances of playing against New England.
Charles has nine carries and five catches this season, for 23 yards apiece. Following the Chiefs' Week 1 loss to the Titans, in which Charles had seven carries, Reid said it was 'negligence' on his part to not get Charles the ball more.
It was the fewest rushing yards Charles had in a game since he carried nine times against the Raiders in Week 14 of the 2012 season.
In 2013, Charles co-led the AFC with 12 rushing touchdowns. He had 1,287 yards on the ground and added 693 receiving yards and seven receiving touchdowns.
Charles is a former third round draft pick in 2008. The 27-year-old has played in Kansas City for his entire career and has been named to the Pro Bowl three times.
The Chiefs are 1-2 this season and are coming off a bye week.
- Molly Geary