Locker injured his right thumb during the Titans' Week 5 loss to the Cleveland Browns and missed last week's win over the Jacksonville Jaguars. He also missed the team's Week 4 loss to the Indianapolis Colts with a wrist injury.
In four games this season, Locker has completed 58 percent of his passes for 764 yards, with four touchdowns and four interceptions. Since being drafted eighth in 2011 out of Washington, he has a 9-13 record as Tennessee's starting quarterback.
With Locker in and out of the lineup, backup Charlie Whitehurst has started two of the past three games. He has thrown for 604 yards, three touchdowns and one interception while completing 58 percent of his passes this season.
The Titans rank 22nd in total offense and 24th in passing offense this season.
Tennessee has opened the season 2-4 and is in third place in the AFC South. The Titans play the Redskins on the road on Sunday at 1 p.m.
- Paul Palladino