Chiefs vs. Giants Final Score Prediction for NFL Week 3 (Can Kansas City Cover?)

Who will win this Sunday Night Football matchup?

Kansas City Chiefs quarterback Patrick Mahomes. / Jay Biggerstaff-Imagn Images

The Kansas City Chiefs are looking to avoid a 0-3 start to the 2025 season when they take on the New York Giants on Sunday Night Football in Week 3. 

New York is coming off an overtime loss to the Dallas Cowboys, and it has yet to win a game this season as well. However, oddsmakers have set the Chiefs as road favorites in the Meadowlands on Sunday.

KC had a brutal stretch to start the season taking on the Los Angeles Chargers in Brazil and the Philadelphia Eagles at home, but can it get back on track in a must-win matchup with the Baltimore Ravens looming in Week 4?

The Giants’ defense may be vulnerable after allowing 37 points in Week 2, and that could be just what the doctor ordered for Mahomes and Andy Reid. 

Each week at SI Betting, we’re attempting to predict the final score of each NFL game as a fun exercise to guide bettors in the total and spread bets for the week’s slate.

Using the latest odds and analysis from our NFL betting team, here’s where I’m leaning for the Chiefs vs. Giants matchup in Week 3. 

Chiefs vs. Giants Odds, Spread and Total

Odds via DraftKings Sportsbook

Spread

• Chiefs -6 (-110)
• Giants +6 (-110)

Moneyline

• Chiefs: -325
• Giants: +260

Total

• 45.5 (Over -108/Under -112)

Unsurprisingly, this line is moving in favor of the Chiefs in Week 3, as they opened as 5.5-point favorites and things have already ticked up to Chiefs -6. 

Patrick Mahomes and company are expected to win in Week 3, but can they cover the spread? 

Chiefs vs. Giants Final Score Prediction

Earlier this week, SI’s NFL betting insider Iain MacMillan shared in his Road to 272 column – where he picks every game, every week – why he’s taking KC to cover on Sunday night: 

The Kansas City Chiefs have looked bad in the first two weeks, but let's cut them a bit of slack, considering how their first two opponents were. The Chargers and the Eagles are tough teams to face, and now they get to face the lowly New York Giants. Let's also point out the Chiefs have a Net Yards per Play of +0.5 through the first two games, which is a better mark than they had last season when they went 15-2.

I'm not looking too far into Russell Wilson throwing for 450 yards against the Cowboys. We've seen enough from him the past few years to know that last week's performance was an anomaly. Despite having a far easier schedule to start the season, the Giants' advanced metrics are on par with the Chiefs, while ranking worse in Net Yards per Play at -0.3.

It’s hard to fade Patrick Mahomes, especially when a potential 0-3 start is on the line. I picked the Chiefs in our Survivor Picks for Week 3, and I’m not wavering from that selection.  

Final Score Prediction: Chiefs 23, Giants 16

---

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

Claim the latest DraftKings promo code offer today. Sign up and place a $5 bet to earn a guaranteed $200 in bonus bets plus over $200 off NFL Sunday Ticket. Regardless of the outcome of your wager,DraftKings will add eight $25 bonus bet tokens to your new account and award one promo code for a discounted NFL Sunday ticket subscription.