Sproles was limited in practice last week after spraining his MCL in Philadelphia's 27-0 win over the New York Giants on Oct. 12.
Campbell had missed two games after his MCL was strained in a chop block against Denver on Oct. 5.
Also inactive for the Eagles is center Jason Kelce, recovering from sports hernia surgery. Kelce returned to practice last week and had been listed as questionable or the game.
Ex-Arizona State running back Marion Grice is active for the first time since he was signed by the Cardinals on Sept. 22.
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