Denver Broncos tight end Julius Thomas (80) runs toward the end zone to score on a 32-yard touchdown reception against the Oakland Raiders during the third quarter of an NFL football game in Oakland, Calif., Sunday, Nov. 9, 2014. (AP Photo/Ben Margot)
Ben Margot
November 16, 2014

ST. LOUIS (AP) Peyton Manning is without two of his top three targets after the Denver Broncos lost tight end Julius Thomas and Emmanuel Sanders to injuries against St. Louis.

Thomas leads the NFL with 12 touchdown catches. He hurt his ankle in the first quarter Sunday.

Sanders caught a 42-yard touchdown pass in the second quarter. But he suffered a concussion on a hard hit from Rams safety Rodney McLeod on the opening drive of the second half.

McLeod was flagged for unnecessary roughness on the play.

Sanders is the Broncos' second-leading receiver, entering the game with 62 catches.

Denver backup running back Montee Ball's return also was questionable after he aggravated a groin injury that sidelined him for five games.

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