NFL odds Week 16: Breaking down betting lines for TNF, Saturday games

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While the Jacksonville Jaguars will be favored for the first time in 43 games when they kick off Week 16 of the NFL season at home against the Tennessee Titans on Thursday Night Football, two Saturday games mean significantly more to the road teams involved.

The Philadelphia Eagles and San Diego Chargers both lost at home to division rivals last week, putting them in virtually must-win situations as they face the Washington Redskins and San Francisco 49ers, respectively.

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Philadelphia fell to the Dallas Cowboys 38-27 as a 3.5-point favorite, per sportsbooks monitored by, on Sunday Night Football. The Eagles were tied atop the NFC East with the Cowboys but now sit one game back in the standings following the loss, so they will need to make up that difference over the last two weeks of the season in order to have any shot at the division crown. The Redskins are 7.5-point home underdogs after losing six straight games and should be just what Philadelphia needs to get back on track. Washington has lost eight of its past 10 home games both straight-up and against the spread, including five in a row.

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The Chargers suffered their second straight home loss last week to the Denver Broncos, 22-10 in an AFC West matchup, with the closing NFL odds showing them as 4.5-point home underdogs. San Diego lost the previous week to New England, 23-14, as four-point dogs and hopes a change of scenery will help on Saturday. San Francisco was mathematically eliminated from the playoffs last Sunday with a 17-7 road loss to the Seahawks, who were nine-point favorites and beat their NFC West rivals for the second time in three games. The 49ers are 2.5-point favorites against the Chargers despite being mired in a three-game losing streak and going 1-7 ATS in their past eight home games, including 1-5 versus the line this year.

The Jaguars versus Titans betting matchup might be the least meaningful of the three NFL games played before Sunday, but do not tell that to the home team. Jacksonville has an excellent opportunity to score its third victory of the season as a three-point favorite, ending the team’s underdog streak at 42 straight games. The Jaguars are 5-2 SU and ATS in their last seven games as favorites, and the Titans have covered just one of the eight previous meetings between the teams despite winning three of the past four in the series.