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The Packers are home favorites against the Lions in Week 1 of the NFL season.

NFL ATS Betting Predictions and Picks for Every Game in Week 1 (Can Packers Cover in NFC North Duel vs. Lions?)

Iain MacMillan

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Sep 4, 2025

Oct 10, 2024; Seattle, Washington, USA; San Francisco 49ers wide receiver Jauan Jennings (15) runs for yards after the catch against Seattle Seahawks cornerback Tre Brown (22) during the second quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

49ers appease Jauan Jennings for now with a modest raise

Grant Cohn

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Sep 4, 2025

San Francisco 49ers wide receiver Jauan Jennings was the team's leading receiver in 2024.

Jauan Jennings Agrees to Restructured Contract With 49ers After Trade Request

Karl Rasmussen

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Sep 3, 2025

Aug 23, 2025; Santa Clara, California, USA; San Francisco 49ers running back Isaac Guerendo (31) runs with the ball during the second quarter against the Los Angeles Chargers at Levi's Stadium. Mandatory Credit: Sergio Estrada-Imagn Images

Why the 49ers Gave up on Isaac Guerendo for Brian Robinson Jr.

Jose Sanchez

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Sep 3, 2025

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Aug 15, 2025; Seattle, Washington, USA; Seattle Seahawks quarterback Sam Darnold (14) reacts following a rushing touchdown by a teammate against the Kansas City Chiefs during the first quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

How the 49ers can Prevent Sam Darnold From Carving Them up Again

Jose Sanchez

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Sep 3, 2025

Jul 23, 2025; Santa Clara, CA, USA; San Francisco 49ers head coach Kyle Shanahan answers questions from reporters following the first day of training camp at SAP Performance Facility. Mandatory Credit: D. Ross Cameron-Imagn Images

49ers HC Kyle Shanahan sounds off on Seahawks HC Mike Macdonald

Grant Cohn

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Sep 3, 2025

Dec 12, 2024; Santa Clara, California, USA; San Francisco 49ers cornerback Deommodore Lenoir (2) is introduced before the start of the game against the Los Angeles Rams at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Deommodore Lenoir Receives a Great Honor From the 49ers

Jose Sanchez

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Sep 3, 2025

Feb 11, 2024; Paradise, Nevada, USA; San Francisco 49ers former quarterback Joe Montana cheers in the first quarter in Super Bowl LVIII against the Kansas City Chiefs at Allegiant Stadium. Mandatory Credit: Stephen R. Sylvanie-Imagn Images

What Joe Montana admires about 49ers QB Brock Purdy's game

Henry Cheal

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Sep 3, 2025

Jan 5, 2025; Glendale, Arizona, USA; San Francisco 49ers head coach Kyle Shanahan looks on after losing to the Arizona Cardinals at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images3

The 49ers are shockingly low in these Week 1 NFL power rankings

Grant Cohn

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Sep 3, 2025

Los Angeles Chargers coach Jim Harbaugh (left) and general manager Joe Hortiz.

Chargers-49ers trade pitch sends disgruntled $15 million playmaker to L.A. for picks

Mike Moraitis

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Sep 3, 2025

Oct 10, 2024; Seattle, Washington, USA; San Francisco 49ers tight end George Kittle (85) drags his toes for a touchdown against the Seattle Seahawks during the second half at Lumen Field. Mandatory Credit: Steven Bisig-Imagn Images

This will determine the winner between 49ers and Seahawks in Week 1

Tom Jensen

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Sep 3, 2025

Aug 15, 2025; Seattle, Washington, USA; Seattle Seahawks quarterback Sam Darnold (14) looks to pass against the Kansas City Chiefs during the first quarter at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn Images

5 new Seahawks the 49ers must be ready for in Week 1

Parker Hurley

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Sep 3, 2025

Brock Purdy and the San Francisco 49ers are significant betting favorites to return to the NFL Postseason.

NFL Playoff Odds for Every Team in 2025 (Bettors Expect 49ers to Return to Postseason)

Iain MacMillan

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Sep 3, 2025

2025 NFL Predictions: Super Bowl, Playoffs and Award Winners From MMQB Staff

The MMQB Staff

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Sep 3, 2025

Will Bijan Robinson smack down the Bucs in Week 1?

NFL Fantasy Football Week 1 Bold Predictions with Alan Goldsher: Bijan Goes Off, Jayden Doesn’t

Alan Goldsher

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Sep 3, 2025

Aug 9, 2025; Santa Clara, California, USA; San Francisco 49ers defensive coordinator Robert Saleh watches from the sidelines in the first quarter against the Denver Broncos at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

This shocking pass rush prediction could swing the 49ers' season

Parker Hurley

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Sep 2, 2025

Aug 9, 2025; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan watches from the sidelines in the first quarter against the Denver Broncos at Levi's Stadium. Mandatory Credit: David Gonzales-Imagn Images

Former 49ers veteran opens up about Kyle Shanahan's leadership style

Henry Cheal

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Sep 2, 2025

5 bold predictions for the San Francisco 49ers offense this season

Parker Hurley

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Sep 2, 2025

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers wide receiver Jauan Jennings (15) warms up before the game against the Arizona Cardinals at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images

How the 49ers Will Use Jauan Jennings Against the Seahawks

Jose Sanchez

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Sep 2, 2025

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