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If the 49ers aren't prepared for this against the Colts, then it will be difficult for them to emerge victorious.
Jose Sanchez|

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Adding pass rusher Matthew Judon would be unwise for the 49ers.
Jose Sanchez|
The 49ers won't come out and say exactly what went down between them and Brandon Aiyuk that led to such a quick and messy divorce. But they will provide clues.
Grant Cohn|
It's not a good sign for these four 49ers to be available against the Colts on Monday night.
Jose Sanchez|
There are two ways for the 49ers to clinch the playoffs this weekend. 
Jose Sanchez|
The San Francisco 49ers may be losing Robert Saleh to a head coaching job
Parker Hurley|
The San Francisco 49ers need the passing game to continue to ascend
Parker Hurley|
This 49er speaks on Brock Purdy's return.
Henry Cheal|
George Kittle is their best offensive weapon.
Henry Cheal|

Game Day

Of all the plays that helped the 49ers defeat the Titans, it was these three that influenced their win the most.
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News

Game planning for the Colts shouldn't be difficult at all for the 49ers' defense.

49ers +

Here's why Sunday's game between the San Francisco 49ers and New York Jets will come down to the final drive.

Betting

Kyle Shanahan reveals how he would handle a 49ers player dropping the ball for a fumble before crossing the goal line.

More 49ers

The surging Seattle Seahawks are off this weekend, but that doesn't mean there are games that considerably help their position in the NFC standings and looming playoffs.
Richie Whitt|
Philip Rivers' limited explosiveness and conservative offense reveal betting value hiding in plain sight.
Michael Greene|
The Houston Texans and New Orleans Saints are among the best survivor pool picks in Week 16.
Michael Rovetto|
The NFC North’s top spot is up for grabs Saturday in Chicago. Plus, Bo Nix faces off against a sturdy Jacksonville defense.
Matt Verderame|
We preview the best, and worst Wide Receiver vs Cornerback matchups of Week 16 Fantasy Football.
Thomas Carelli|
Nine teams can punch their ticket to the postseason this weekend, including the Patriots, Jaguars, Bills and Chargers in the AFC and the Eagles, 49ers and Seahawks in the NFC.
Matt Verderame|
The Indianapolis Colts must emerge victorious against the San Francisco 49ers to keep playoff hopes alive.
Drake Wally|
Skyler Bell’s first catch this fall wasn’t just a building block for the best season of any receiver in UConn history. The play—an 80-yard touchdown against Cen
Daniel Flick|