Brock Purdy Injury Update: 49ers QB Considered 'Week-to-Week' With Toe Injury

Purdy is missing his third game this season on Thursday night.

49ers quarterback Brock Purdy could miss more time with a toe injury. / Darren Yamashita-Imagn Images

Brock Purdy is missing his third game of the season on Thursday night in the 49ers' NFC West showdown vs. the Rams as he's dealing with toe soreness.

The San Francisco quarterback wanted to try and play on Thursday night, even though it was a quick turnaround for the 49ers. He felt toe soreness after playing on Sunday vs. the Jaguars, having previously missed Week 2 and 3 with turf toe and a left shoulder injury.

Apparently, though, Purdy was "not close" to starting Thursday night, NFL Network's Ian Rapoport reported, despite him leaving the window open to play. Purdy underwent an MRI on his toe this week, revealing that he re-aggravated the turf toe injury. At this point, the quarterback is considered "week-to-week" and could miss Week 6 vs. the Buccaneers.

From The @NFLonPrime TNF pregame show: #49ers QB Brock Purdy suffered a setback of his turf toe injury against the #Jaguars and is now considered week-to-week. He could miss additional games after tonight. pic.twitter.com/dRYqj0nK5S

— Ian Rapoport (@RapSheet) October 2, 2025

In Purdy's absence, Mac Jones has gone 2-0 as the 49ers' starter. He is starting in Thursday night's matchup vs. the Rams as well. Jones could see a lot more playing action if Purdy is out for longer than just this week.

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