Quarless injured his knee in the second quarter of the Packers' 38-28 victory over the Kansas City Chiefs on Monday night, and was later ruled out for the second half.
The tight end had two catches for 14 yards prior to exiting the game.
Packers' wide receiver Davante Adams also left Monday's game early after re-aggravating his sprained ankle in the Packers' opening series.
Quarless missed the start of training camp in late July after his daughter died at birth. The six-year NFL veteran was arrested in Miami earlier this summer after he fired two rounds from a .45 caliber weapon after an argument with a group of women outside a South Beach parking lot.
- Beth Maiman