Bethea seemed to have hurt himself on play toward the end of the second quarter. On the play, Bethea was flagged for a facemask penalty against Seattle receiver Doug Baldwin.
Jaquiski Tartt, a rookie safety, took over for Bethea.
Bethea has 39 combined tackles and one sack over six games this season.
The Seahawks went on to defeat San Francisco 20–3.
- Xandria James