After the Bills jumped out to an early 3–0 lead in the first quarter against the Jaguars in London, Jacksonville surged back in front with 27 unanswered points thanks to two consecutive pick-sixes from QB EJ Manuel.
The score was 27–3 with under three minutes to play in the first half, but Buffalo was able to cut the lead to 14.
After a dormant third quarter, the Bills were off to the races. After a Dan Carpenter field goal brought it to 27–16, Manuel found Marcus Easley for a 58-yard touchdown, followed by a two-point conversion.
With the score now 31–27 Bills, Bortles and wideout Allen Hurns helped Jacksonville take back the lead.
The Bills got the ball back, but Manuel was unable to convert on a 4th-and-1 around midfield with under a minute remaining.
Buffalo fell to 3–4 with the loss and sits behind New York and New England in the AFC East. The Jaguars picked up their second win of the season to improve to 2–5 in a clustered AFC South.
- Kenny Ducey