Cardinals vs. Reds Prediction, Odds, Probable Pitchers, Prop Bets for Monday, April 28

The Cincinnati Reds are riding a four-game win streak ahead of an important series in the NL Central against the St. Louis Cardinals.

Both teams are hoping to catching the 17-12 Chicago Cubs, who are leading the division by 1.5 games over the Reds.

Let's dive into the odds and my best bets for tonight's series-opener.

Cardinals vs. Reds Odds, Run Line, and Total

Odds via DraftKings Sportsbook

Run Line

Cardinals -1.5 (+154)
Reds +1.5 (-185)

Moneyline

Cardinals +102
Reds -122

Total

9.5 (Over -105/Under -115)

Cardinals vs. Reds How to Watch

Date: Monday, April 28
Game Time: 6:40 PM EST
Venue: Great American Ball Park
How to Watch (TV): FanDuel Sports Network Ohio, FanDuel Sports Network Midwest, MLBN (out-of-market only)
Cardinals Record: 12-16
Reds Record: 15-13

Cardinals vs. Reds Probable Pitchers

St. Louis: Andre Pallante, RHP (2-1, 4.05 ERA)
Cincinnati: Nick Martinez, RHP (0-3, 5.40 ERA)

Cardinals vs. Reds Best Prop Bet

Nick Martinez UNDER 4.5 Strikeouts (-140) via DraftKings

The Cardinals enter tonight's game with the sixth-lowest strikeout rate in Major League Baseball, striking out on just 20.2% of their plate appearances. Nick Martinez will get the start for the Reds tonight and he's failed to reach five or more strikeouts in three of his five starts in 2025. He has a tough test ahead of him tonight if he wants to record 5+ strikeouts, therefore, I'll be the UNDER.

Cardinals vs. Reds Prediction and Pick

Let's sit back and root for runs in this divisional showdown. The Cardinals and Reds rank eighth and ninth in OPS this season while combining for 10 runs per game in 2025, a tough above tonight's set total of 9.5.

Tonight's pitching matchup doesn't make me think this is going to be a defensive duel either. Andre Pallante enters with a 4.05 ERA and Nick Martinez has a 5.40 ERA. Keep an eye on the Cardinals' bullpen as well. They have a 4.80 bullpen ERA, which ranks 25th amongst all teams.

This game has all the makings of an offensive shootout. Take the OVER.

Pick: OVER 9.5 (-105) via DraftKings

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You can check out all of Iain's bets here!