Giants vs. Bills Prediction, Odds, Spread, Trends for NFL Preseason Week 1

A battle in the state of New York is set to take place in the opening week of the NFL Preseason when the Buffalo Bills welcome the New York Giants for an exhibition showdown.

One of the stories of the preseason is the loaded Giants' quarterback room with Russell Wilson, Jameis Winston, Jaxson Dart, and Tommy DeVito all taking snaps. Wilson is likely to be the Week 1 starter, but a strong preseason by any of the other options could lead to Wilson having a short leash once the regular season begins.

Let's take a look at the odds and my best bets for this interconference preseason matchup.

Giants vs. Bills Odds, Spread, and Total

Odds via FanDuel Sportsbook

Spread

Giants -1.5 (-110)
Bills +1.5 (-110)

Moneyline

Giants -125
Bills +105

Total

OVER 37.5 (-110)
UNDER 37.5 (-110)

Giants vs. Bills How to Watch

Date: Friday, August 8
Time: 1:00 p.m. ET
Venue: Highmark Stadium
How to Watch (TV): NFL Network
Giants Record: 0-0
Bills Record: 0-0

Giants vs. Bills Betting Trends

Brian Daboll is 4-5 SU and 1-8 ATS in the preseason as a head coach
Sean McDermott is 17-9 ATS in the preseason as a head coach

Giants vs. Bills Prediction and Pick

It hasn't been announced how much starters will play for both teams in this game, but Brian Daboll did mention on Monday that he could see the starters play some in this game. Even if they don't, the Giants' depth at quarterback makes them an interesting option in this game. If Wilson doesn't play, I expect Winston to take plenty of snaps. Dart and DeVito would also be interesting options. I have faith in them to put up some points against the Bills.

The biggest downside for the Bills this season is that it could be argued they're top-heavy. If they deal with injuries to a few key starters, they could end up a season like the San Francisco 49ers experienced last year. That means they could be ripe for fading in the preseason when the majority of snaps will be taken by the backups.

I'll take the Giants in this battle of New York.

Pick: Giants -1.5 (-110) via FanDuel

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You can check out all of Iain's bets here!