NFL ATS Betting Predictions and Picks for Every Game in Week 6 (Can Chargers Cover After BYE Week Rest?)

It's been an unpredictable start to the NFL season but now that we have five weeks in the rear view mirror, we're starting to have a better idea of which teams are for real and which teams are fade-worthy the rest of the season.
There are 14 games on the Week 6 slate and as they have done every week this season, Sports Illustrated's Jennifer Piacenti and Iain MacMillan will make their spread pick for every single game.
Let's take a look at how they've been doing with this tough challenge so far this season and then we'll take a look at their Week 6 picks.
Week 5 Records
- Jennifer Piacenti: 5-8-1 (-3.45 units)
- Iain MacMillan: 8-5-1 (+2.27 units)
Season-to-Date Records
- Jennifer Piacenti: 35-42-1 (-10.84 units)
- Iain MacMillan: 40-37-1 (-0.83 units)
All odds listed below are via DraftKings Sportsbook.
49ers (-3.5) vs. Seahawks
- Jennifer Piacenti: Seahawks
- Iain MacMillan: Seahawks
Jaguars vs. Bears (-2)
- Jennifer Piacenti: Jaguars
- Iain MacMillan: Bears
Commanders vs. Ravens (-6.5)
- Jennifer Piacenti: Commanders
- Iain MacMillan: Commanders
Texans (-7) vs. Patriots
- Jennifer Piacenti: Texans
- Iain MacMillan: Texans
Browns vs. Eagles (-9)
- Jennifer Piacenti: Eagles
- Iain MacMillan: Eagles
Cardinals vs. Packers (-5)
- Jennifer Piacenti: Packers
- Iain MacMillan: Packers
Buccaneers (-3.5) vs. Saints
- Jennifer Piacenti: Buccaneers
- Iain MacMillan: Buccaneers
Colts (-1) vs. Titans
- Jennifer Piacenti: Colts
- Iain MacMillan: Titans
Chargers (-3) vs. Broncos
- Jennifer Piacenti: Chargers
- Iain MacMillan: Broncos
Steelers (-3) vs. Raiders
- Jennifer Piacenti: Steelers
- Iain MacMillan: Raiders
Falcons (-6) vs. Panthers
- Jennifer Piacenti: Panthers
- Iain MacMillan: Falcons
Lions (-3) vs. Cowboys
- Jennifer Piacenti: Cowboys
- Iain MacMillan: Lions
Bengals (-3.5) vs. Giants
- Jennifer Piacenti: Giants
- Iain MacMillan: Bengals
Bills (-2) vs. Jets
- Jennifer Piacenti: Jets
- Iain MacMillan: Bills
Odds refresh periodically and are subject to change.
If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.
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Originally from Nova Scotia, Iain MacMillan is a senior editor covering betting, with a focus on NFL, NHL, and golf. He hosts the Bacon Bets Podcast and has been featured on VSIN, BetQL and Monumental Sports Network. He is a member of the Metropolitan Golf Writers Association and his beloved Falcons and Maple Leafs break his heart on a yearly basis.
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Jennifer Piacenti is a fantasy sports and betting analyst for Sports Illustrated. She serves as a host for Sirius XM Fantasy Sports Radio and has her own podcast, “Waiver Wired,” on the Extra Points podcast network. Piacenti is also a featured expert on MLB Network’s “Bettor’s Eye” and is a member of the esteemed Tout Wars, the fantasy baseball battle of the experts. She is a member of the Fantasy Sports Writers Association and is a 2020 Scott Fish Bowl finalist.
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