NFL Straight-Up Moneyline Picks for Every Game in Week 10

SI Staff | Nov 5, 2025

The SI Team makes their picks for Week 10 of the 2025 NFL Season. / Sports Illustrated

With Week 9 in the books, we are now officially halfway through the 2025 NFL season. As difficult as it is to finish a season profitable with your picks, two of our eight SI panelists have managed to hold a winning record through the first nine weeks. Matt Verderame is at 91-4301 for +4.47 units, and Conor Orr is at an impressive mark of 89-45-1 for +11.11 units.

It's time to move on to the second half of the 2025 campaign. The team has its picks locked in for Week 11, so let's jump into them.

Week 9 Results

• Clare Brennan, Associate Editor 9-5 (+0.86 units)
• Mitch Goldich, Senior Editor 8-6 (-1.24 units)
• Gilberto Manzano, NFL Staff Writer 9-5 (+0.89 units)
• Conor Orr, Senior Writer 11-3 (+4.78 units)
• John Pluym, NFL Managing Editor 6-8 (-5.51 units)
• Matt Verderame, NFL Staff Writer 9-5 (-0.19 units)
• Iain MacMillan, Senior Editor, Betting 6-8 (-5.56 units)
• Peter Dewey, Associate Managing Editor, Betting 8-6 (-2.24 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 86-48-1 (-4.37 units)
• Mitch Goldich, Senior Editor 86-48-1 (-3.89 units)
• Gilberto Manzano, NFL Staff Writer 75-69 (-18.8 units)
• Conor Orr, Senior Writer 89-45-1 (+11.11 units)
• John Pluym, NFL Managing Editor 81-53-1 (-12.24 units)
• Matt Verderame, NFL Staff Writer 91-43-1 (+4.47 units)
• Iain MacMillan, Senior Editor, Betting 77-57-1 (-12.19 units)
• Peter Dewey, Associate Managing Editor, Betting 88-47-1 (-4.15 units)

NFL Week 10 Picks

SI NFL moneyline picks for Week 10. / Sports Illustrate

All odds are via DraftKings Sportsbook

Raiders (+380) vs. Broncos (-500)

• Clare Brennan: Broncos
• Mitch Goldich: Broncos
• Gilberto Manzano: Broncos
• Conor Orr: Broncos
• John Pluym: Broncos
• Matt Verderame: Broncos
• Iain MacMillan: Broncos
• Peter Dewey: Broncos

Falcons (+245) vs. Colts (-205)

• Clare Brennan: Colts
• Mitch Goldich: Colts
• Gilberto Manzano: Colts
• Conor Orr: Colts
• John Pluym: Colts
• Matt Verderame: Colts
• Iain MacMillan: Colts
• Peter Dewey: Colts

Giants (+160) vs. Bears (-192)

• Clare Brennan: Bears
• Mitch Goldich: Bears
• Gilberto Manzano: Bears
• Conor Orr: Bears
• John Pluym: Bears
• Matt Verderame: Bears
• Iain MacMillan: Giants
• Peter Dewey: Bears

Bills (-455) vs. Dolphins (+350)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Bills
• Iain MacMillan: Bills
• Peter Dewey: Bills

Ravens (-225) vs. Vikings (+185)

• Clare Brennan: Vikings
• Mitch Goldich: Ravens
• Gilberto Manzano: Ravens
• Conor Orr: Ravens
• John Pluym: Vikings
• Matt Verderame: Ravens
• Iain MacMillan: Ravens
• Peter Dewey: Ravens

Browns (-142) vs. Jets (+120)

• Clare Brennan: Jets
• Mitch Goldich: Jets
• Gilberto Manzano: Jets
• Conor Orr: Browns
• John Pluym: Jets
• Matt Verderame: Jets
• Iain MacMillan: Browns
• Peter Dewey: Browns

Patriots (+120) vs. Buccaneers (-142)

• Clare Brennan: Patriots
• Mitch Goldich: Buccaneers
• Gilberto Manzano: Patriots
• Conor Orr: Buccaneers
• John Pluym: Patriots
• Matt Verderame: Buccaneers
• Iain MacMillan: Patriots
• Peter Dewey: Buccaneers

Saints (+200) vs. Panthers (-245)

• Clare Brennan: Panthers
• Mitch Goldich: Panthers
• Gilberto Manzano: Panthers
• Conor Orr: Saints
• John Pluym: Panthers
• Matt Verderame: Panthers
• Iain MacMillan: Saints
• Peter Dewey: Panthers

Jaguars (+105) vs. Texans (-125)

• Clare Brennan: Jaguars
• Mitch Goldich: Jaguars
• Gilberto Manzano: Jaguars
• Conor Orr: Jaguars
• John Pluym: Jaguars
• Matt Verderame: Texans
• Iain MacMillan: Texans
• Peter Dewey: Jaguars

Cardinals (+245) vs. Seahawks (-305)

• Clare Brennan: Seahawks
• Mitch Goldich: Seahawks
• Gilberto Manzano: Seahawks
• Conor Orr: Seahawks
• John Pluym: Seahawks
• Matt Verderame: Seahawks
• Iain MacMillan: Seahawks
• Peter Dewey: Seahawks

Rams (-198) vs. 49ers (+164)

• Clare Brennan: Rams
• Mitch Goldich: Rams
• Gilberto Manzano: Rams
• Conor Orr: Rams
• John Pluym: 49ers
• Matt Verderame: Rams
• Iain MacMillan: Rams
• Peter Dewey: Rams

Lions (-535) vs. Commanders (+400)

• Clare Brennan: Lions
• Mitch Goldich: Lions
• Gilberto Manzano: Lions
• Conor Orr: Lions
• John Pluym: Lions
• Matt Verderame: Lions
• Iain MacMillan: Lions
• Peter Dewey: Lions

Steelers (+140) vs. Chargers (-166)

• Clare Brennan: Steelers
• Mitch Goldich: Steelers
• Gilberto Manzano: Chargers
• Conor Orr: Chargers
• John Pluym: Chargers
• Matt Verderame: Steelers
• Iain MacMillan: Steelers
• Peter Dewey: Steelers

Eagles (+114) vs. Packers (-135)

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Eagles
• John Pluym: Eagles
• Matt Verderame: Packers
• Iain MacMillan: Packers
• Peter Dewey: Eagles

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