NFL Straight-Up Moneyline Picks for Every Game in Week 18

Iain MacMillan | 1 Hour Ago

SI Roundtable Records / Sports Illustrated

The final week of the 2025 NFL season is finally here! That means it's the last week for the SI Roundtable and it's everyone's final opportunity to build on their 2025 record. Conor Orr has run away with the win, up +16.59 units entering the final week, and Matt Verderame is clinging to a profitable record at +4.35 units.

It's time to take a look at everyone's picks for the final week of the 2025 NFL regular season.

Week 17 Results

• Clare Brennan, Associate Editor 9-7 (-3.42 units)
• Mitch Goldich, Senior Editor 11-5 (+0.64 units)
• Gilberto Manzano, NFL Staff Writer 9-7 (-2.87 units)
• Conor Orr, Senior Writer 9-7 (-3.1 units)
• John Pluym, NFL Managing Editor 7-9 (-6.72 units)
• Matt Verderame, NFL Staff Writer 9-7 (-3.32 units)
• Iain MacMillan, Senior Editor, Betting 9-7 (-1.93 units)
• Peter Dewey, Associate Managing Editor, Betting 9-7 (-2.73 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 162-93-1 (-8.66 units)
• Mitch Goldich, Senior Editor 166-89-1 (-2.28 units)
• Gilberto Manzano, NFL Staff Writer 153-112-1 (-18.14 units)
• Conor Orr, Senior Writer 169-66-1 (+16.59 units)
• John Pluym, NFL Managing Editor 152-103-1 (-27.08 units)
• Matt Verderame, NFL Staff Writer 171-84-1 (+4.35 units)
• Iain MacMillan, Senior Editor, Betting 150-105-1 (-12.9 units)
• Peter Dewey, Associate Managing Editor, Betting 161-95-1 (-11.17 units)

NFL Week 18 Picks

NFL Week 18 picks / Sports Illustrated

All odds via FanDuel Sportsbook

Panthers (+124) vs. Buccaneers (-146)

• Clare Brennan: Buccaneers
• Mitch Goldich: Panthers
• Gilberto Manzano: Buccaneers
• Conor Orr: Buccaneers
• John Pluym: Buccaneers
• Matt Verderame: Panthers
• Iain MacMillan: Panthers
• Peter Dewey: Panthers

Seahawks (-112) vs. 49ers (-104)

• Clare Brennan: 49ers
• Mitch Goldich: Seahawks
• Gilberto Manzano: 49ers
• Conor Orr: Seahawks
• John Pluym: 49ers
• Matt Verderame: 49ers
• Iain MacMillan: Seahawks
• Peter Dewey: Seahawks

Colts (+450) vs. Texans (-600)

• Clare Brennan: Texans
• Mitch Goldich: Texans
• Gilberto Manzano: Texans
• Conor Orr: Texans
• John Pluym: Texans
• Matt Verderame: Texans
• Iain MacMillan: Texans
• Peter Dewey: Texans

Cowboys (-205) vs. Giants (+170)

• Clare Brennan: Cowboys
• Mitch Goldich: Cowboys
• Gilberto Manzano: Cowboys
• Conor Orr: Cowboys
• John Pluym: Cowboys
• Matt Verderame: Cowboys
• Iain MacMillan: Cowboys
• Peter Dewey: Cowboys

Browns (+310) vs. Bengals (-390)

• Clare Brennan: Bengals
• Mitch Goldich: Bengals
• Gilberto Manzano: Bengals
• Conor Orr: Bengals
• John Pluym: Bengals
• Matt Verderame: Bengals
• Iain MacMillan: Bengals
• Peter Dewey: Bengals

Saints (+140) vs. Falcons (-166)

• Clare Brennan: Saints
• Mitch Goldich: Saints
• Gilberto Manzano: Saints
• Conor Orr: Falcons
• John Pluym: Falcons
• Matt Verderame: Saints
• Iain MacMillan: Saints
• Peter Dewey: Saints

Packers (+220) vs. Vikings (-270)

• Clare Brennan: Packers
• Mitch Goldich: Vikings
• Gilberto Manzano: Vikings
• Conor Orr: Packers
• John Pluym: Vikings
• Matt Verderame: Vikings
• Iain MacMillan: Packers
• Peter Dewey: Vikings

Titans (+590) vs. Jaguars (-850)

• Clare Brennan: Jaguars
• Mitch Goldich: Jaguars
• Gilberto Manzano: Jaguars
• Conor Orr: Jaguars
• John Pluym: Jaguars
• Matt Verderame: Jaguars
• Iain MacMillan: Jaguars
• Peter Dewey: Jaguars

Cardinals (+280) vs. Rams (-350)

• Clare Brennan: Rams
• Mitch Goldich: Cardinals
• Gilberto Manzano: Rams
• Conor Orr: Rams
• John Pluym: Rams
• Matt Verderame: Rams
• Iain MacMillan: Rams
• Peter Dewey: Rams

Chargers (+570) vs. Broncos (-820)

• Clare Brennan: Broncos
• Mitch Goldich: Broncos
• Gilberto Manzano: Broncos
• Conor Orr: Broncos
• John Pluym: Chargers
• Matt Verderame: Broncos
• Iain MacMillan: Broncos
• Peter Dewey: Broncos

Commanders (+265) vs. Eagles (-330)

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Eagles
• John Pluym: Eagles
• Matt Verderame: Eagles
• Iain MacMillan: Eagles
• Peter Dewey: Eagles

Chiefs (-275) vs. Raiders (+225)

• Clare Brennan: Chiefs
• Mitch Goldich: Chiefs
• Gilberto Manzano: Chiefs
• Conor Orr: Raiders
• John Pluym: Chiefs
• Matt Verderame: Chiefs
• Iain MacMillan: Chiefs
• Peter Dewey: Chiefs

Dolphins (+490) vs. Patriots (-670)

• Clare Brennan: Patriots
• Mitch Goldich: Patriots
• Gilberto Manzano: Patriots
• Conor Orr: Patriots
• John Pluym: Patriots
• Matt Verderame: Patriots
• Iain MacMillan: Patriots
• Peter Dewey: Patriots

Lions (+134) vs. Bears (-158)

• Clare Brennan: Bears
• Mitch Goldich: Bears
• Gilberto Manzano: Lions
• Conor Orr: Bears
• John Pluym: Lions
• Matt Verderame: Bears
• Iain MacMillan: Bears
• Peter Dewey: Bears

Jets (+290) vs. Bills (-360)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Jets
• Iain MacMillan: Bills
• Peter Dewey: Bills

Ravens (-184) vs. Steelers (+154)

• Clare Brennan: Ravens
• Mitch Goldich: Ravens
• Gilberto Manzano: Ravens
• Conor Orr: Ravens
• John Pluym: Ravens
• Matt Verderame: Ravens
• Iain MacMillan: Steelers
• Peter Dewey: Ravens

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