White Sox vs. Giants Prediction, Odds, Probable Pitchers, Prop Bets for Friday, May 22

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The San Francisco Giants are hoping that a return home can get them back on track as they start a weekend set against the Chicago White Sox.
The Giants started their road trip with two wins over the Dodgers, but lost the final two games in Los Angeles, took two of three over the A’s, then got swept in Arizona.
The White Sox started their road trip by losing two of three in Seattle after a strong homestand.
Here are the odds, probable pitchers, and predictions for White Sox vs. Giants on Friday, May 22.
White Sox vs. Giants Odds, Run Line and Total
Odds via DraftKings Sportsbook
Run Line
- White Sox -1.5 (+153)
- Giants +1.5 (-186)
Moneyline
- White Sox -114
- Giants -105
Total
- 7.5 (Over +100/Under -131)
White Sox vs. Giants Probable Pitchers
- White Sox: Davis Martin (6-1, 1.61 ERA)
- Giants: Trevor McDonald (2-0, 2.37 ERA)
Davis Martin has found something this season for the White Sox. He’s allowed more than two runs in a start just once, and that came back in March. Since then, he’s allowed one run or fewer in seven of eight starts, including each of his last six.
Trevor McDonald has also been great in his three starts for the Giants. He’s allowed five runs in 19 innings against the Padres, Dodgers, and A’s.
White Sox vs. Giants How to Watch
- Date: Friday, May 22
- Time: 10:15 p.m. ET
- Venue: Oracle Park
- How to Watch (TV): CHSN, NBCSBA
- White Sox record: 25-24
- Giants record: 20-30
White Sox vs. Giants Best MLB Prop Bets
White Sox Best MLB Prop Bet
- Davis Martin UNDER 2.5 Earned Runs (-158)
As outlined above, Martin has been nothing short of spectacular this season. He’s cashed this in eight straight starts, and went UNDER 1.5 ER in six straight outings.
The Giants just scored eight runs in their three losses in Arizona, and Oracle Park isn’t exactly a hitter-friendly stadium.
White Sox vs. Giants Prediction and Pick
While neither of these starters is a household name, this is a great pitching matchup in San Francisco.
Both teams are scuffling a bit offensively as well.
I love the UNDER tonight in San Francisco.
Pick: UNDER 7.5 (-131)
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Odds refresh periodically and are subject to change.
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Ryan is a sports betting writer at Sports Illustrated. He has experience working for NHL.com, NBC Sports, Covers, and more throughout his decade in the industry. As a Philadelphia native, he understands the passion and pain that come with being a sports fan.
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