MONTE TERMINILLO, Italy (AP) ��� Nairo Quintana of Colombia repeated his dominant performance on Tirreno-Adriatico's high mountains to win the fourth stage and move into the overall lead on Saturday.
Movistar rider Quintana waited until the final five kilometers to increase his pace and then pulled clear with two kilometers left to win on the Terminillo for the second straight year, finishing 18 seconds ahead of Geraint Thomas.
Adam Yates was third, 24 seconds behind Quintana at the end of the 187-kilometer (116-mile) ride from Montalto di Castro to Monte Terminillo - the toughest leg of the Tirreno-Adriatico.
Quintana took over the lead from Rohan Dennis and was 33 seconds ahead of Yates overall. Thibaut Pinot was third, 56 seconds behind Quintana.
"I wasn't sure of what I could do today as I had been sick a few days ago but our tactic was to have someone ahead before I launched my attack and that's what happened with (Jonathan) Castroviejo," Quintana said. "The advantage I have on GC now is significant. It gives me some confidence ahead of the second half of the race."
It is the first time the leader's jersey has left the BMC team this week.
The fifth stage on Sunday is a 210-kilometer (130-mile) ride from Rieti to Fermo, which has steep climbs in the second half of the route.
The race finishes on Tuesday.