The move comes one day after Uehara allowed solo homers by Mark Teixeira and Chase Headley in the ninth inning that lifted the New York Yankees to a 5-4 win. It was Uehara's third loss in five outings and his third straight blown save opportunity.
Manager John Farrell says Edward Mujica will become the closer. He also says Uehara has no physical ailments and is not being shut down for the season.
Last year, Uehara was 4-1 with a 1.09 ERA and 21 saves in 24 opportunities. In the postseason, he was 1-1 with a 0.68 ERA and seven saves in seven chances as Boston won its third championship since 2004.