Perez has pitched in a career-high 65 games this season and thinks he could appear in more, but manager Kirk Gibson said he needs to rest more.
"He's not hurt," Gibson said. "There's just not much coming out. He's got a dead arm. He hit a wall."
The 33-year-old has not pitched since Sept. 14.
According to AZCentral, over the weekend the velocity on Perez's fastball dropped by two miles per hour from the previous week.
Perez has a 2.86 ERA with 70 strikeouts in 56.2 innings this season.
The Diamondbacks are 62-90 and in fourth place in the NL West. They begin a four-game road series against the Rockies Thursday night.
- Molly Geary