Though Jeter has 260 career home runs, he has hit just four this season. Only one has come at home.
The over/under for the number of total hits, runs and RBI on the night for Jeter is set at two.
People can also bet on whether Jeter will hit a home run in any at-bat in the final game.
Jeter is set to retire after 20 seasons. The Yankees finish the year with a three-game weekend series at the Boston Red Sox.
GALLERY: Derek Jeter's retirement gifts
Derek Jeter's Farewell Tour Gifts
- Sarah Barshop