The Astros fired manager Bo Porter earlier this month during his second season with the club. He had a 110-190 record as Houston's manager.
Lovullo has been Boston's bench coach for the past two seasons. Previously, he was first base coach for John Farrell's staff with the Toronto Blue Jays.
His most recent managerial job was with the Pawtucket Red Sox in 2010. Including his time in the Cleveland Indians system, he has a 661-609 record as a minor league manager.
The Astros' 69-90 record is the fifth-worst mark in baseball this season.
- Paul Palladino