Cespedes hit a grand slam and a two-run homer off Quintana, and Shane Greene pitched seven more impressive innings to help the Detroit Tigers rout the Chicago White Sox 9-1 on Sunday. Cespedes is 6 for 8 with four home runs against Quintana for his career.
''It's a bad day, I forget that and keep working hard every time,'' Quintana said. ''I have confidence in me every time we go out there. The next start, make the adjustment and do better.''
It was the first major league grand slam for Cespedes.
''Any ballplayer that hits two home runs is feeling good,'' Cespedes said through a translator. ''I couldn't be luckier to be on such a great team with such a good group of ballplayers.''
Greene (3-0) allowed his first earned run of the season Sunday when an RBI triple by Jose Abreu skipped past J.D. Martinez in right field in the sixth. Greene gave up five hits and four walks, but the White Sox hit into four double plays.
Greene, acquired in the offseason from the New York Yankees, struck out three.
Cespedes came up with two out and the bases loaded in the first. As a wind-whipped rain began to fall, the Detroit slugger sent a drive over the fence in left on a full count to make it 4-0.
''I keep the ball down with him, he's a power hitter,'' Quintana said. ''But 3-2 I tried to throw the ball away but the ball went to the middle and it's a mistake.''
Cespedes hit his second homer of the game in the third to give the Tigers a 7-0 lead. It was the third homer of the season and 74th career shot for Cespedes, who has won the All-Star Home Run Derby the last two years.
The Tigers (10-2) are off to the best start of any team in baseball, and the defending AL Central champions rebounded from a 12-3 loss to the White Sox on Saturday. Detroit leads the division by one game over Kansas City, which has the American League's second-best record.
Chicago's pitchers came into the game with a 1.79 ERA in their previous 50 1-3 innings, but Quintana was in trouble pretty much throughout. He allowed nine runs and 10 hits in four-plus innings.
''It seemed like he was getting ahead 0-2 or 1-2 on almost every hitter, but then he would start nibbling instead of going after them,'' manager Robin Ventura said. ''He kept ending up 3-2 and then he'd come in with a pitch that would catch too much of the plate. Q's going to be better than this - I'm not worried about him.''
Greene has been a strong addition so far in a Detroit starting rotation that lost Max Scherzer to free agency and Rick Porcello via a trade. He allowed an unearned run in his first start against Minnesota, then went eight scoreless innings at Pittsburgh.
The walks could have been a problem against the White Sox, but Chicago never put together a big rally.
''I was doing my best to throw strikes. When I wasn't throwing strikes and I was putting guys on base, the defense was turning two,'' Greene said. ''They make it a lot easier when they're doing that.''
White Sox: RHP Jake Petricka (right forearm) is on a rehab assignment with Triple-A Charlotte. He pitched a scoreless inning Saturday night against Gwinnett.
Tigers: Manager Brad Ausmus said reliever Joe Nathan (right elbow) will need to pitch on a rehab assignment or in a simulated game before returning for the Tigers. He is eligible to come back Wednesday from the DL.