The club made the moves late Sunday night, following hours of speculation they might be prepared to bring up shortstop Francisco Lindor, the top prospect in Cleveland's organization.
Instead, they sent Chisenhall, batting just .209 with four homers and 19 RBIs in 52 games, to the Clippers. Ramirez, too, will report to the minors after batting .180 with eight RBIs in 46 games.
Urshela will make his major league debut Tuesday against Seattle. At Columbus, he batted .275 with three homers and nine RBIs in 21 games. He missed the exhibition season with lower back inflammation.
Walters has spent most of the season with the Clippers, batting .259 with two homers and 15 RBIs. He appeared in seven games earlier this season with the Indians.