Manager John Farrell said he was waiting to see how Ortiz felt before posting the lineup. About 45 minutes later, the club listed the lineup without Ortiz's name.
The 39-year old Ortiz is hitting .231 with 15 homers and 43 RBIs. He went 2 for 3 with a walk in Saturday's 5-3 win.
Ortiz has played first base twice in this eight-game homestand, which concludes against the Yankees. It's the first time he's played first in Fenway Park since 2005.
The Red Sox are looking to win their fifth straight series.