A look at what's happening all around the major leagues Wednesday:
Jon Lester looks to win his fifth consecutive decision for the Cubs. Lester has a 2.04 ERA in his past five outings after going more than two months without a victory. The Tigers will counter with rookie Daniel Norris, who has a 4.76 ERA in three starts since joining Detroit from Toronto in the David Price trade.
Derek Holland will make his first appearance in more than four months, returning from a torn shoulder muscle, an injury sustained in Texas' home opener April 10. Holland missed the first five months of the 2014 season because of an offseason knee injury and has thrown just 38 innings over the past two seasons combined. Rookie Mike Montgomery throws for Seattle.
Mets rookie Noah Syndergaard tries to regain the dominance he showed in July in the finale of a two-game set in Baltimore. The 22-year-old has a 4.74 ERA in three August starts after posting a 1.32 ERA in five outings last month. Ubaldo Jimenez will pitch for Baltimore. He's 2-4 with a 5.56 ERA in eight starts since the end of June.
Mark Buehrle will pitch on extra rest for the second straight start as Toronto wraps a two-game series against Philadelphia. Blue Jays manager John Gibbons gave the 36-year-old six days off before his last start because the veteran was ''a little beat up,'' and the left-hander limited Oakland to two runs over seven innings. He'll pitch on five days of rest against the Phillies and has quality starts in 12 of his past 13 outings, going 8-5 with a 2.16 ERA in that span.
The Pirates send out J.A. Happ for the third time since acquiring him from Seattle for a minor league pitcher. Happ had one of his best starts this year his last time out, striking out seven Mets over 5 1-3 innings of one-run ball. Robbie Ray (3-8, 3.29) gets the ball for the Diamondbacks.