FOX's Jay Glazer reported just before kickoff of Sunday's Buccaneers-Saints game that Brees would be playing in the Superdome for the last time in his 20-year career.
Campbell, 44, has spent the past five years as the assistant head coach and tight ends coach for the New Orleans Saints, and played in the NFL for 11 seasons.
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Tom Brady threw for two touchdowns and rushed for another as Tampa Bay ended the game on a 17-0 run.
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Winston's first pass attempt on Sunday was a 56-yard touchdown to wide receiver Tre'Quan Smith.