This will be the first Packers game without Brett Favre since 1991.
The Mike Martz Bowl. The new offensive coordinator for the 49ers will be looking to run up the score on his former team.
A rematch of the AFC championship game. The Patriots have eliminated the Chargers from the playoffs the past two years.
Unlike last year's rain-soaked stinker between the Dolphins and Giants, this year's game at Wembley Stadium is a possible Super Bowl preview.
The first of two games between the defending NFC East champ and the defending Super Bowl champ.
The NFL's best rivalry resumes. The Colts will be seeking payback after the Pats came back from 10 down to win 24-20 in Week 9.
The Chargers have had the Colts' number, beating them twice last season.
Remember how the Colts tanked it against the Titans, inadvertently causing the Browns to miss the playoffs? Cleveland sure does.
The NFL invades CFL territory when the Bills make their regular-season debut in Toronto.
The Seahawks final regular-season game could possibly be Mike Holmgren's final game in the NFL.