Most Rushing Yards In NFL Openers

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O.J. Simpson: 250 yards, 2 TDs
Arian Foster: 231 yards, 3 TDs
Michael Turner: 220 yards, 2 TDs
Eddie George: 216 yards, TD
George Rogers: 206 yards, 2 TDs
Gerald Riggs: 202 yards, 2 TDs
Duce Staley: 201 yards, TD
Norm Bulaich: 198 yards, TD
Curtis Martin: 196 yards, TD
Alan Ameche: 194 yards, TD
Ottis Anderson: 193 yards, TD
Eric Dickerson: 193 yards, 2 TDs