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NFL Odds: Popular prop bets to keep an eye on in Week 5

The Broncos host the undefeated Arizona Cardinals on Sunday in Denver, and all eyes will be on Peyton Manning as he is one touchdown pass away from becoming the second quarterback in NFL history to pass for 500 touchdowns. One prop bet this week asks which Denver Broncos player will be the one to catch Manning's milestone touchdown pass.

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Julius Thomas has caught five of Manning's eight touchdown passes this season and is a 2/1 favorite to catch No. 500. Demaryius Thomas (7/2), Emmanuel Sanders (7/2), Wes Welker (6/1), Jacob Tamme (7/1), Monte Ball (15/2) and Any Other Player (10/1) round out the list.

Tales of the Tape: Breaking down key Week 5 matchups

​Meanwhile, in Indianapolis, the Colts are 2-0 straight up and against the spread over their last two games, outscoring their opponents 85-34 over that stretch. The Colts will try to keep things rolling at home against the Baltimore Ravens this Sunday.

Andrew Luck has thrown for 370 or more yards and four touchdowns in each of his last two games. Can he accomplish that feat for a third straight week? Bettors that think Luck will pass for 370 or more yards and four touchdowns this week can bet the “Yes” at +1000 at sportsbooks monitored by OddsShark.com. The “No” side is going off at -2000.

In less-reliable quarterback news, the Bills have benched EJ Manuel in favor of Kyle Orton this week going on the road to face the Detroit Lions. How will Kyle Orton fare in his starting role? His line for total passing yards is set at 240.5 yards at sportsbooks monitored by OddsShark.com. The touchdown line is set at 1.5 with the UNDER favored at -200 over the OVER at +160.

Which of the league's two 0-4 teams will win a game first? Jacksonville is a -200 favorite to pick up its first win before Oakland at +150. The Jaguars have shown some signs of life under rookie quarterback Blake Bortles and have some winnable games on the horizon hosting Pittsburgh, visiting Tennessee and then hosting Cleveland and Miami. Oakland has a bye this week and returns with home games against two teams that have looked formidable so far: the Chargers and Cardinals.