Denver Broncos executive vice president John Elway supports a London-based team and says players would adjust to a team based in England.
The NFL has played at Wembley Stadium each season since 2007 and three regular season games will be played in London this season. Teams have been given a bye the following week to recover from the transatlantic flight, though the league has said that setup would not work with a full-time London team.
Elway dismissed concerns about the viability of a team making London its hometown.
"I think everyone in this league is getting used to adjusting. We have Monday night games, Sunday night games, Thursday night games - our players do a tremendous job of adjusting."
He went on to stress the importance of the NFL playing regular season games in London.
"First of all I think it's great we're playing three over there," he said. "It exposes everyone over there to our game of football, especially regular season games because they count. The people get to see what it's all about. I definitely think there's a possibility of some day having an NFL franchise over there."
In September, the Miami Dolphins defeated the Oakland Raiders in London. The Atlanta Falcons and Detroit Lions play in London in Week 8, and the Jacksonville Jaguars and Dallas Cowboys play the final game in London in Week 10.
This is the second of four straight seasons the Jaguars will play a "home" game in London as part of the NFL's International Series.
Other professional leagues also play regular season games overseas. In recent years, Major League Baseball has had teams open their seasons in Japan and Australia, and the National Basketball Association has had mid-season games in London and Mexico City.
- Paul Palladino