And promptly led his team to a touchdown in a 26-10 loss.
Manziel entered with 12:01 left in the fourth quarter, and Cleveland trailing 20-3. Manziel then capped an eight-play, 80-yard drive with a 10-yard touchdown run.
He came in after Hoyer was intercepted by Da'Norris Searcy and Buffalo's Dan Carpenter hit a 34-yard field goal.
It was his first appearance Week 3, when he had a few plays in a 23-21 loss to Baltimore. Manziel ran for 3 yards on the first play from scrimmage. He then completed his first NFL pass on the next play, a 12-yard completion to Miles Austin.
He finished 5 for 8 for 63 yards in the loss and rushed for 13 yards.
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