Gipson was having a Pro Bowl-caliber season, leading the NFL with six interceptions when he hurt his knee on Nov. 23. He had hoped to return, but the Browns put him on IR before traveling to Carolina on Saturday.
Gipson is still tied for the league lead in interceptions.
The 24-year-old finished with 52 tackles in 11 starts and had a 62-yard interceptions return for a touchdown. Gipson led the Browns with five interceptions last season.
To take Gipson's roster spot, the Browns promoted linebacker Scott Solomon from the practice squad.
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