Ryan called the injury ''devastating'' to both the Bills and Wynn, and said that Wynn will miss the season if an ACL tear is confirmed.
Wynn was injured in Friday's preseason opener against Carolina. He played 11 games for the Bills last season, picking up two sacks and 17 tackles.
Wynn was entering his eighth season. He has 10 1/2 sacks between Buffalo, Green Bay, Dallas, San Diego and Tennessee.
Buffalo also added kicker Dan Carpenter to the active roster, moving him off the active/non-football injury list.
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