Colts quarterback Andrew Luck will miss his first NFL game on Sunday against Jacksonville with a right shoulder injury.
He had started the first 57 games of his career, including the playoffs.
Luck was limited in practice all week and the move allows him to get a few more days of rest before the Colts visit Houston on Thursday.
Also, the Panthers are without star linebacker Luke Kuechly for the third straight week. He's out because of a concussion suffered during the season opener against Jacksonville.
Houston running back Arian Foster is set to make his debut this season. He missed the first three games of the season after tearing his groin early in training camp.
Bears quarterback Jay Cutler makes his first start since he strained a hamstring in the first half of a 48-23 loss to Arizona on Sept. 20. He will be without one of his favorite targets in wide receiver Alshon Jeffery, who is out for the third straight week with a hamstring injury.
Tight end Vernon Davis is out for the 49ers' game against the Green Bay Packers, while running back Reggie Bush is returning for the first time since injuring his left calf in a Week 1 win against Minnesota on Sept. 14.
JACKSONVILLE AT INDIANAPOLIS
Colts: QB Andrew Luck, CB Greg Toler, RB Tyler Varga, DT T.Y. McGill, OT Denzelle Good, G Todd Herremans, TE Dwayne Allen.
Jaguars: WR Marqise Lee, RB Denard Robinson, S Sergio Brown, G Brandon Linder, TE Julius Thomas, DE Chris Smith, DT Sen'Derrick Marks.
OAKLAND AT CHICAGO
Raiders: RB Taiwan Jones, CB Keith McGill, C Rodney Hudson, G Jon Feliciano, DT Matt McCants, DE Benson Mayowa, DL C.J. Wilson
Bears: QB David Fales, P Patrick O'Donnell, WR Alshon Jeffery, RB Ka'Deem Carey, C Hroniss Grasu, OT Jermon Bushrod, NT Jeremiah Ratliff.
GREEN BAY AT SAN FRANCSICO
Packers: QB Brett Hundley; WR Davante Adams; CB Demetri Goodson; S Morgan Burnett; LB Jake Ryan; G Lane Taylor; T Brian Bulaga.
49ers: TE Vernon Davis; WR DeAndrew White; RB Mike Davis; CB Shareece Wright; G/C Ian Silberman; NT Mike Purcell; G/T Brandon Thomas.
CLEVELAND AT SAN DIEGO
Browns: DB Joe Haden, RB Robert Turbin, DB K'Waun Williams, LB Craig Robertson, LB Scott Solomon, TE E.J. Bibbs, DL Desmond Bryant.
Chargers: WR-KR Jacoby Jones, CB Craig Mager, S Jahleel Addae, OLB Tourek Williams, C Chris Watt, G Orlando Franklin, T King Dunlap.
MINNESOTA at DENVER
Vikings: QB Taylor Heinicke, WR Charles Johnson, CB Jabari Price, S Andrew Sendejo, LB Edmond Robinson, TE Chase Ford, DE Justin Trattou.
Broncos: QB Trevor Siemian, S-KR Omar Bolden, OLB Lerentee McCray, G Shelley Smith, LT Ty Sambrailo, TE Mitchell Henry, DE Kenny Anunike.
NEW YORK GIANTS AT BUFFALO
Giants: WR Victor Cruz, DE Robert Ayers, TE Daniel Fells, S Cooper Taylor, LB Jasper Brinkley, DT Markus Kuhn, TE Jerome Cunningham.
Bills: WR LeSean McCoy, WR Sammy Watkins, S Aaron Williams, G John Miller, WR Marquise Goodwin, LB Tony Steward, DE Alex Carrington.
PHILADELPHIA AT WASHINGTON
Eagles: QB Thad Lewis, S Chris Maragos, LB Kiko Alonso, OL Julian Vandervelde, DE Cedric Thornton, LB Marcus Smith, and DE Taylor Hart
Redskins: QB Robert Griffin III, WR DeSean Jackson, WR Andre Roberts, CB DeAngelo Hall, LB Perry Riley Jr., DE Kedric Golston, and OT Tom Compton.
HOUSTON AT ATLANTA
Falcons: S Ricardo Allen, RB Tevin Coleman, C Gino Gradkowski, WR Justin Hardy, WR Devin Hester, T Jake Long, TE Jacob Tamme
Texans: S Lonnie Ballentine, OLB Kourtnei Brown, ILB Akeem Dent, RB Jonathan Grimes, C Greg Mancz, WR Jaelen Strong, WR Chandler Worthy
CAROLINA AT TAMPA BAY
Panthers: S Dean Marlowe, RB Brandon Wegher, LB Luke Kuechly, T Daryl Williams, G Amini Silatolu, WR Kevin Norwood, WR Jerricho Cotchery.
Buccaneers: QB Ryan Griffin, CB Johnthan Banks, S Major Wright, C Evan Smith, TE Austin Seferian-Jenkins, TE Luke Stocker, WR Russell Shepard.
KANSAS CITY AT CINCINNATI
Chiefs: QB Aaron Murray, WR Albert Wilson, CB Steven Nelson, LB Dezman Moses, OL Jah Reid, TE Brian Parker, DL Rakeem Nunez-Roches.
Bengals: WR Greg Little, WR Mario Alford, S George Iloka, TE C.J. Uzomah, DT Marcus Hardison, DT Brandon Thompson, DE Margus Hunt.
ST. LOUIS at ARIZONA
Rams: QB Sean Mannion, S Maurice Alexander, RB Chase Reynolds, OT Darrell Williams, OT Andrew Donnal, DE Eugene Sims.
Cardinals: QB Matt Barkley, WR J.J. Nelson, RB Andre Ellington, LB Shaq Riddick, OG/C Ted Larsen, OT D.J. Humphries, NT Xavier Williams.
DALLAS AT NEW ORLEANS
Cowboys: WR Dez Bryant, WR Lucky Whitehead, QB Matt Cassel, OL La'El Collins, TE Geoff Swaim, DE Randy Gregory, DE Ryan Russell
Saints: RG Jahri Evans, WR Joe Morgan, DB Kyle Wilson, DE Obum Gwacham, DT Kaleb Eulls, TE Michael Hoomanawanui, QB Garrett Grayson.
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