Amendola filled in admirably, making 10 catches for 79 yards against the Giants, and the Patriots will need a similar performance Monday night against the Buffalo Bills to remain unbeaten.
''I'm just going to focus on my abilities and what I can do,'' said Amendola, now in year three with New England. ''Try to put the best product on the field.''
Ever since, Amendola has played second fiddle to Edelman among the wideouts.
''He's a great player,'' Amendola said. ''He did a lot for our offense, made a lot of big plays.''
Aaron Dobson, a third-year receiver with 12 catches for 124 yards in seven games, could also help fill the void despite playing in just under 30 percent of the Patriots' offensive snaps.
''His timing, his overall technique and consistency has improved,'' Patriots head coach Bill Belichick said. ''I know it doesn't always show up on Sundays, but I'd say he's had a good year.''
Edelman had been Brady's favorite target through nine games, leading the team with 61 catches - twelve more than star tight end Rob Gronkowski - for 692 yards and seven touchdowns.
''You wish you could just plug someone else in, but that's impossible,'' Brady said. ''Julian Edelmans just aren't sitting out on the street, or else they'd be playing for another team.''
Amendola has 19 fewer catches than Edelman, totaling 403 yards and two touchdowns this season, but has done enough to earn the trust of his coach - dating back to his Patriots debut in 2013 when he had 10 catches for 104 yards in a season-opening victory against the Bills.
''He's made a lot of big plays for us in critical situations,'' Belichick said. ''Very dependable guy, great hands. I know Buffalo two years ago, the catches he made in that game were remarkable.''
Tom Brady reflected on the career of Boston Red Sox designated hitter David Ortiz, who announced he will retire after the 2016 season. ''A great player. He's given all of our fans so much reason to cheer,'' Brady said. ''He's been an incredible player, be sad to see him go. I've got a lot of respect for him and the way that he's always I think brought a great leadership to his team. He's been a great example.'' . New England signed TE Joseph Fauria, nephew of former Patriots tight end Christian Fauria, to its practice squad Wednesday. ''I've always kind of followed him,'' said Brady, who met him during a workout at UCLA. ''We'll see what he can do. Hopefully he can contribute. If it's in the gene pool, then I think we're in a good place.'' The Patriots also signed CB Chris Greenwood and released DBs Ross Ventrone and Dewey McDonald. . K Stephen Gostkowski was named AFC Special Teams Player of the Week following his game-winning 54-yard field goal Sunday in New York.