Manning was scheduled to have his walking boot removed Friday afternoon so he can begin rehab on his injured left foot.
Coach Gary Kubiak said Manning will stay in Denver with safety T.J. Ward and nose tackle Sylvester Williams, both of whom have ankle injuries, when the Broncos (9-2) and Brock Osweiler face the Chargers (3-8) on Sunday.
Manning will miss his third straight game with a torn plantar fascia.
Linebacker DeMarcus Ware (back) also was ruled out but will make the trip.
Manning said he was going to remove his boot at 5:30 p.m. MT, exactly 10 days after he was placed in a cast by foot specialist Dr. Robert Anderson.
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