Coach Rex Ryan updated Woods' status on Monday following the Bills' 35-25 loss at Washington.
Woods finished the game, but Ryan said the injury is severe enough to end Woods' season.
Running back LeSean McCoy is scheduled to undergo an MRI on his right knee to determine his status, Ryan said. McCoy left in the third quarter of Sunday's game and did not return.
Buffalo (6-8) hosts Dallas (4-10) on Sunday.
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