Manning finished the game 13–of–23 for 141 yards with no touchdowns and one interception.
The Broncos advanced to Super Bowl 50 with a 20–18 victory over the Patriots in the AFC Championship Game.
Manning's appearance in Super Bowl 50 will marked Manning's fourth appearance in the league's title game.
Super Bowl XLI: Colts 29, Bears 17
In Manning's first Super Bowl, he had to face the Chicago Bears. The Bears boasted one of the league's best defenses during the 2006 season, only allowing 15.9 points per game, third–best in the NFL that year.
In a driving rain, the Bears took an early lead. But Manning rallied the Colts, outscoring Chicago 23–3 over the game's final three quarters. Manning's stats weren't particularly impressive—he finished the game 25–of–38 with 247 yards and one touchdown and an interception—but he led the Colts to a dominant 29–17 victory.
"It was a wonderful team game," Manning said after the game. "Everyone did their job."
Manning's first title silenced critics who charged that the quarterback's regular-season success didn't translate to the postseason.
Super Bowl XLIV: Saints 31, Colts 17
After finishing the season 14–2, the Colts were favored entering Super Bowl XLIV in Miami.
Manning's first–quarter touchdown pass to Pierre Garcon helped the Colts to a 10–0 lead, but the Saints rallied and took the lead early in the third quarter. After the lead changed hands twice more, the Saints held a 24–17 advantage late in the fourth quarter. Manning drove the Colts into Saints territory, but a critical error from Manning gave the Saints their first Super Bowl title.
Tracy Porter's interception for a touchdown would give New Orleans a 31–17 lead, which would stand as the final score. Manning finished the game 31–of–45 for 333 yards with one touchdown and one interception.
Super Bowl XLVIII: Seahawks 43, Broncos 8
Super Bowl XLVIII turned into an extended lowlight reel for the Broncos and Peyton Manning. Denver boasted the league's best offense during the 2013 season, but the Broncos were thoroughly outplayed by the Seahawks in every aspect of the game.
On the first offensive play of the game, Broncos center Manny Ramirez snapped the ball over Manning's head near the end zone, resulting in a safety. It continued getting worse for Denver: The Seahawks led 22–0 at the half, and the game was essentially over in the third quarter. The Seahawks led 36–0 before the Broncos finally scored, a 14-yard touchdown pass from Manning to Demaryius Thomas.
Manning finished the game 34–of–49 for 280 yards with one touchdown and two interceptions, one of which was returned for a touchdown.
Super Bowl 50: Broncos 24, Panthers 10
Manning certainly didn't have his best game in Super Bowl 50, finishing the contest 13–of–23 for 141 yards with no touchdowns and one interception. Denver's defense carried the Broncos to a title, and Manning's offense did just enough to overcome the favored Panthers.
After winning Super Bowl 50, Manning said he would take some time to consider his NFL future before announcing whether he would retire.