With Jimmy Garoppolo starting for the Patriots, Carson Wentz behind center for the Eagles and Shaun Hill or Sam Bradford - who really knows? - throwing passes for Minnesota, the first week of the NFL season will play out Sunday with plenty of uncertainty about what to expect.
Other players expected to be absent in Week 1 include Patriots tight end Rob Gronkowski and Chiefs running back Jamaal Charles, while some are returning from injury, including Green Bay wideout Jordy Nelson and Ravens quarterback Joe Flacco.
The early games include: Tampa Bay at Atlanta, Minnesota at Tennessee, Cleveland at Philadelphia, Cincinnati at New York Jets, Oakland at New Orleans, San Diego at Kansas City, Buffalo at Baltimore, Chicago at Houston and Green Bay at Jacksonville.
Games expected to start after 4 p.m. Eastern include: Miami at Seattle, New York Giants at Dallas and Detroit at Indianapolis, with New England playing Arizona on Sunday night.