CAROLINA (6-10) at SAN FRANCISCO (2-14)
Sunday, 4:25 p.m. EDT, Fox
OPENING LINE - Panthers by 5.
SERIES RECORD - Panthers lead 12-8
LAST MEETING - Panthers beat 49ers 46-27, Sept. 18, 2016
AP PRO32 RANKING - Panthers No. 13, 49ers No. 26
PANTHERS OFFENSE - OVERALL (19), RUSH (10), PASS (21T).
PANTHERS DEFENSE - OVERALL (21), RUSH (6), PASS (29).
49ERS OFFENSE - OVERALL (31), RUSH (4), PASS (32).
49ERS DEFENSE - OVERALL (32), RUSH (32), PASS (14).
STREAKS, STATS AND NOTES - Panthers won past five regular-season meetings. Niners won playoff game following 2013 season. ... San Francisco's previous regular season win vs. Carolina came Nov. 18, 2001. ... Each team's top picks starred at nearby Stanford: Carolina RB Christian McCaffrey and San Francisco DL Solomon Thomas. ... Panthers return to Levi's Stadium for first time since losing Super Bowl to Denver in February 2016. ... Carolina's Greg Olsen became first TE with three straight 1,000-yard receiving seasons. ... Panthers QB Cam Newton last in NFL in 2016 with 52.9 completion rate. ... DE Julius Peppers returns to Carolina after seven seasons in Chicago, Green Bay. Peppers leads active players with 143+ sacks. ... Head coaching debut for San Francisco's Kyle Shanahan. ... Niners won six straight openers for longest active streak in NFL. ... Niners edge rusher Elvis Dumervil has 99 sacks. ... San Francisco QB Brian Hoyer no INTs in 200 passes last season for Chicago. ... Fantasy Tip: San Francisco RB Carlos Hyde excels in openers. Hyde has 306 yards rushing, five TDs in 3 career Week 1 games.
AP NFL website: www.pro32.ap.org and http://twitter.com/AP-NFL