Romelu Lukaku scored a hat trick in Everton's 4-1 victory at Young Boys and Napoli also enjoyed a big away win as the Europa League resumed with the first legs of last-32 matches on Thursday.
While Napoli thrashed Trabzonspor 4-0 to virtually book its place in the last 16, it was a frustrating night for two other Italian teams as Roma was held 1-1 at home by Feyenoord and Torino was pegged back in a 2-2 home draw with Athletic Bilbao.
The build-up to the Roma-Feyenoord match was marred by fans of the Dutch visitors clashing with police, injuring several officers in a rampage through the capital city.
Everton came from behind in Switzerland thanks to Lukaku's three goals and a close-range strike from Seamus Coleman. The English club had defender John Stones sent off for denying a scoring opportunity in the 63rd when the score was 4-1, but Guillaume Hoarau — the scorer of Young Boys' goal and the man fouled — blazed the penalty over the crossbar.
Napoli powered into a 3-0 lead after 27 minutes through goals by Henrique, Gonzalo Higuain and Manolo Gabbiadini, with Duvan Zapata adding a fourth in second-half stoppage time soon after Dries Mertens has missed a penalty for the Italians.
Roma has drawn its last five home games in Serie A to drop seven points behind leader Juventus, and it was held again by Feyenoord after taking the lead through Ivory Coast forward Gervinho. Colin Kazim Richards equalized in the 55th.
Two goals from Maxi Lopez put Torino in front after falling behind to Inaki Williams' ninth-minute strike. Carlos Gurpegi scored a 73rd-minute leveler for the Spanish side.
Dutch striker Bas Dost continued his fine scoring form with both goals for Wolfsburg in its 2-0 win over Sporting Lisbon, taking his tally to 10 goals in his last six games in all competitions.
There were also wins for Zenit St. Petersburg, Dnipro Dnipropetrovsk and Club Brugge.