Bills running back Fred Jackson is expected to miss the remainder of the 2012 season with a knee sprain, according to CBSSports.com's Jason La Canfora via Twitter:
Bills coach Chan Gailey said Jackson would miss just 2-3 weeks on a Monday morning radio show.
Jackson injured his knee in the fourth quarter of the Bills' 15-12 loss to the Rams. It is Jackson's second injury to the same knee this season.
Jackson was sidelined the last six games of 2011 with a broken leg, ending a streak of 61 consecutive games beginning in the 2007 season.