Wade is getting treatment for a bone bruise which he suffered when he collided knees with Bulls forward Jimmy Butler in the second quarter of Monday's 88-65 Game 4 victory.
The Heat lead the best-of-seven series 3-1 series with Game 5 set for Wednesday night in Miami.
Wade scored six points in Game Four on 3-of-10 shooting and played 29 minutes. Wade is averaging just 12.3 points in the playoffs and just 11.3 points through four games against the Bulls.
"His status hasn't changed," Heat head coach Erik Spoelstra said of Wade, via ESPN.com. "We all know what he's dealing with. He's day to day. We'll evaluate him today. We'll evaluate him tomorrow and go from there."