Nash has been out since a Feb. 11 loss against the Utah Jazz, when he played 17 minutes and recorded two assists and one rebound. He has dealt with myriad injuries this season, including having an ongoing nerve-root irritation in his left leg.
The Lakers have already ruled guard Kobe Bryant out for the remainder of the season as he continues to rehab from a knee injury.
Nash, 40, has only played in 10 games this season for the Lakers (22-42), who have one of the worst records in the Western Conference.
"He's not going to play," D'Antoni said about Nash, via the Los Angeles Times.